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Tutorial

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Poll

How frequently do you perform fundus autofluorescence imaging in patients with GA?

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Every appointment
   
Every 6 months
   
Every 9 months
   
Every 12 months
   

Tutorial

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Poll

Which area of GA treatment would you like to know more about?

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Efficacy and safety data for complement inhibitor therapies
   
Utilizing complement inhibitor therapies in clinical practice
   
Emerging complement inhibitor therapies
   
Alternative therapeutic pathways
   

Tutorial

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Poll

What do you think is the biggest challenge in the early diagnosis of GA?

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Lack of early symptoms
   
Limited awareness amongst clinicians
   
Need for specialized imaging
   
Differential diagnosis from other retinal diseases
   
 
Early identification of GA
New and emerging therapies for GA
Monitoring treatment outcomes in GA
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Macular Degeneration, Imaging, Retina/Vitreous CE/CME accredited

touchIN CONVERSATION
A relaxed discussion between two faculty focussed on real world clinical issues. Useful tips below will show how to navigate the activity. Join the conversation. Close

Recent advances in the care of patients with geographic atrophy: Bringing new and emerging therapies into focus

  • Select in the video player controls bar to choose subtitle language. Subtitles available in English, German, French, Italian, Spanish.
  • A practice aid is available for this activity in the Toolkit
  • Downloads including slides are available for this activity in the Toolkit
Learning Objectives

After watching this activity, participants should be better able to:

  • Outline the progression of geographic atrophy (GA) and approaches to support early diagnosis and intervention
  • Interpret the latest data on mechanisms of action, efficacy and safety for agents used in the treatment of GA and their implications for clinical practice
  • Discuss the value of imaging techniques, metrics and endpoints for the treatment of GA and how they may be incorporated into clinical practice
Overview

In this activity, two experts discuss recent advances in the care of patients with geographic atrophy (GA). They explore the importance of early identification of GA and how this can be achieved, examine the potential impact of new and emerging therapies for GA, and highlight key practical considerations for monitoring treatment outcomes and evaluating effectiveness of therapy in clinical practice. read more

Target Audience

This activity has been designed to meet the educational needs of ophthalmologists, retina specialists and optometrists involved in the management of patients with GA.

USF Accreditation

Disclosures

USF Health adheres to the Standards for Integrity and Independence in Accredited Continuing Education. All individuals in a position to influence content have disclosed to USF Health any financial relationship with an ineligible organization. USF Health has reviewed and mitigated all relevant financial relationships related to the content of the activity. The relevant relationships are listed below. All individuals not listed have no relevant financial relationships.

Faculty

Prof. Giuseppe Querques discloses: Consultant and/or advisory board fees from 4DMT, AbbVie, Apellis, Bausch & Lomb, Bayer, Boehringer Ingelheim, EyePoint, Heidelberg Engineering, iCARE-CenterVue, Lumithera, Novartis, Roche, Sandoz, ThƩa Pharmaceuticals and Zeiss.

Dr Arshad M. Khanani discloses: Consultant fees from 4DMT, AbbVie, ADARx Pharmaceuticals, Adverum, Alcon, Alkeus, Allgenesis, Amgen, Annexin, Annexon, Apellis Pharmaceuticals, Ashvattha Therapeutics, Astellas, Aviceda Therapeutics, Beacon Therapeutics, Boehringer Ingelheim, Clearside Biomedical, Complement Therapeutics, Exegenesis, EyePoint Pharmaceuticals, Fronterra Therapeutics, Genentech, Gyroscope Therapeutics, Harrow, i-Lumen Scientific, InFocus, Iveric Bio, Janssen Pharmaceuticals, Kodiak Sciences, Kriya Therapeutics, Kyowa Kirin, Merit, Neurotech, Nanoscope, Novartis, Ocular Therapeutix, Oculis, Ocuphire, OcuTerra, Ollin, Olive BioPharma, Opthea, Opus Genetics, Oxular, Oxurion, Perfuse, Ray Therapeutics, Recens Medical, Regeneron Pharmaceuticals, Regenxbio, Revive, RevOpsis, Roche, Samsung Biologics, Sanofi, Stealth BioTherapeutics, Surrozen, ThƩa Pharmaceuticals, Therini, Unity Biotechnology, Vanotech, Vial and ZipBio. Grants/research support from 4DMT, Adverum, Alexion, Annexon, Apellis Pharmaceuticals, Astellas, Aviceda Therapeutics, Complement Therapeutics, Eyepoint Pharmaceuticals, Exegenesis, Genentech, Gyroscope Therapeutics, Iveric Bio, Janssen, Kodiak, Kyowa Kirin, Neurotech, Ocular Therapeutix, Oxular, Regenxbio, Roche, Sanofi and Vanotech. Stock/Shareholder (self-managed) Ashvattha Therapeutics, Aviceda Therapeutics, Oculis, Ollin, Opthea, PolyPhotonix, Recens Medical, Perfuse, RevOpsis, Vial and ZipBio.

Content Reviewer

Danielle Walker, DNP, APRN, AGNP-C, has no financial interests/relationships or affiliations in relation to this activity.

Touch Medical Contributor

Hannah Fisher has no financial interests/relationships or affiliations in relation to this activity.

USF Health Office of Continuing Professional Development and touchIME staff have no financial interests/relationships or affiliations in relation to this activity.

Requirements for Successful Completion

In order to receive credit for this activity, participants must review the content and complete the post-test and evaluation form. Statements of credit are awarded upon successful completion of the post-test and evaluation form.

If you have questions regarding credit please contact cpdsupport@usf.eduĀ 

Accreditations

Physicians

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through a joint providership of USF Health and touchIME. USF Health is accredited by the ACCME to provide continuing medical education for physicians.

USF Health designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditsTM.Ā  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Advanced Practice Providers

Physician Assistants may claim a maximum of 0.75 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1Ā CreditTM from organizations accredited by ACCME or a recognized state medical society.

The AANPCP accepts certificates of participation for educational activities approved for AMA PRA Category 1Ā CreditTM by ACCME-accredited providers. APRNs who participate will receive a certificate of completion commensurate with the extent of their participation.

Date of original release: 8 May 2025. Date credits expire: 8 May 2026.

If you have any questions regarding credit, please contact cpdsupport@usf.edu

EBACĀ® Accreditation

touchIME is an EBACĀ® accredited provider since 2023.

This program is accredited by the European Board for Accreditation of Continuing Education for Health Professionals (EBACĀ®) for 50 minutes of effective education time.

EBACĀ® holds an agreement on mutual recognition of substantive equivalency with the US Accreditation Council for CME (ACCME) and the Royal College of Physicians and Surgeons of Canada, respectively.

Through an agreement between the European Board for Accreditation of Continuing Education for Health Professionals (EBACĀ®) and the American Medical Association, physicians may convert EBACĀ® External CME credits to AMA PRA Category 1 Creditsā„¢. Information on the process to convert EBACĀ® credit to AMA credit can be found on the AMA website. Other healthcare professionals may obtain from the AMA a certificate of having participated in an activity eligible for conversion of credit to AMA PRA Category 1 Creditā„¢.

EBACĀ® is a member of the International Academy for CPD Accreditation (IACPDA) and a partner member of the International Association of Medical Regulatory Authorities (IAMRA).

Faculty Disclosure Statement/Conflict of Interest Policy

In compliance with EBACĀ® guidelines, all speakers/chairpersons participating in this programme have disclosed or indicated potential conflicts of interest which might cause a bias in the presentations. The Organizing Committee/Course Director is responsible for ensuring that all potential conflicts of interest relevant to the event have been mitigated and declared to the audience prior to the CME activities.

Requirements for Successful Completion

Certificates of Completion may be awarded upon successful completion of the post-test and evaluation form. If you have completed one hour or more of effective education through EBACĀ® accredited CE activities, please contact us at accreditation@touchime.org to receive your EBACĀ® CE credit certificate. EBACĀ® grants 1 CE credit for every hour of education completed.

Date of original release: 8 May 2025. Date credits expire: 8 May 2027.

Time to complete: 50 minutes

If you have any questions regarding the EBACĀ® credits, please contact accreditation@touchime.orgĀ 

This activity is CE/CME accredited

To obtain the CE/CME credit(s) from this activity, please complete this post-activity test.

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  • Select in the video player controls bar to choose subtitle language. Subtitles available in English, German, French, Italian, Spanish.
  • A practice aid is available for this activity in the Toolkit
  • Downloads including slides are available for this activity in the Toolkit

Topics covered in this activity

Macular Degeneration / Imaging / Retina/Vitreous
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touchIN CONVERSATION
Recent advances in the care of patients with geographic atrophy: Bringing new and emerging therapies into focus
0.75 CE/CME credit

Question 1/5
Your 74-year-old patient is experiencing central vision loss and difficulty with low-light vision. You suspect your patient has late-stage age-related macular degeneration and is at risk of developing GA. Which tool would you preferentially use to identify lesions that are associated with developing GA?

GA, geographic atrophy.

OCT is a high-resolution, non-invasive, rapid imaging technique that delivers comprehensive information about the various layers of the retina. Recommendations from an expert panel considering the identification and management of GA suggest that OCT is the preferred imaging method to identify GA due to its ease of use and accessibility among optometrists and ophthalmologists. The most common output of ophthalmologic OCT, the B-scan, shows a cross-sectional image of the macula where the structural integrity of the inner and outer photoreceptors, retinal pigment epithelium, Bruch’s membrane and choroid can be readily assessed in a rapid, non-invasive manner.

Abbreviations
GA, geographic atrophy; OCT, optical coherence tomography.

Reference
Regillo CD, et al. Clin Ophthalmol. 2024;18:325–35.

Question 2/5
You have a 75-year-old patient with geographic atrophy. Their BMI is 27.5, they smoke 10 cigarettes a day, drink 5–6 units of alcohol per week, do a small amount of weekly exercise and eat a mostly plant-based diet. What do you advise your patient in order to help reduce disease progression?

BMI, body mass index.

The development of GA is influenced by various modifiable and non-modifiable risk factors, including age, diet and specific genetic variants, particularly those involving regulators of the complement system.1,2 Cigarette smoking has consistently been demonstrated to be a strong risk factor for the development of late age-related macular degeneration, including GA, and faster GA progression.2 A higher intake of whole fruits, lower intake of red meat, moderate alcohol consumption and a higher intake ratio of monounsaturated to saturated fatty acids are all associated with a slower progression of GA.2

Abbreviations
GA, geographic atrophy.

References

  1. Antonio-Aguirre B and Arevalo JF. Int J Retina Vitreous. 2023;9:72.
  2. Keenan TDL. Ophthalmol Sci. 2023;3:100306.
Question 3/5
Which of the following statements is true regarding the efficacy of pegcetacoplan and avacincaptad pegol in phase III clinical trials in patients with geographic atrophy?

In the phase III OAKS and DERBY clinical trials, pegcetacoplan slowed GA lesion growth compared with sham, with treatment effects increasing over time in both monthly and every-other-month dosing groups.1 The GALE extension trial of OAKS and DERBY demonstrated a reduction in GA growth rate up to 36 months.2 Two-year data from the GATHER2 clinical trial demonstrated that the treatment effect of 2 mg avacincaptad pegol, administered monthly or every other month, more than doubled over 2 years vs 1 year, relative to sham.3

Abbreviation
GA, geographic atrophy.

References

  1. Heier JS, et al. Lancet. 2023;402:1434–48.
  2. Abbey AM, et al. Invest Ophthalmol Vis Sci. 2024;65:380.
  3. Khanani AM, et al. Presented at: 127th AAO Annual Meeting, San Francisco, CA, USA. 3–6 November 2023.
Question 4/5
You are initiating treatment with a complement inhibitor (assuming availability for use in your region) for your patient with geographic atrophy. Following the third injection, your patient develops new neovascularization. What would you do to help manage this?

VEGF, vascular endothelial growth factor.

According to real-world data presented at Angiogenesis 2025, 1.8% and 0.6% of eyes in patients with geographic atrophy developed choroidal neovascularization following treatment with the complement inhibitors pegcetacoplan and avacincaptad pegol, respectively.1 The increased incidence of neovascularization associated with intravitreal complement inhibitors can be managed with concurrent anti-VEGF therapy. Many clinicians elect to treat with anti-VEGF and complement inhibition at separate visits.2

Abbreviation
VEGF, vascular endothelial growth factor.

References

  1. MacCumber MW. Presented at: Angiogenesis 2025, Virtual congress. 8 February 2025.
  2. Asahi DO, et al. Retina Specialist. 2024;9:22–5.
Question 5/5
You are considering which imaging technique to use to monitor treatment efficacy in a patient with GA. Which of the following statements is true regarding the use of FAF?

FAF, fundus autofluorescence; GA, geographic atrophy.

FAF is clinically useful to visualize the total area of GA lesions, visualize focality characteristics and provide information concerning location relative to the fovea. It can be used to identify specific lesion characteristics through distinct patterns of hyperautofluorescence along lesion borders, which may have implications in predicting the rate of GA progression.

Abbreviations
FAF, fundus autofluorescence; GA, geographic atrophy.

Reference
Regillo CD, et al. Clin Ophthalmol. 2024;18:325–35.

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